Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.

The Arf tumor suppressor acts as a sensor of oncogenic signals, countering aberrant proliferation GREY/WHITE HAIR SHAMPOO in large part via activation of the p53 transcriptional program, though a number of p53-independent functions have been described.Mounting evidence suggests that, in addition to promoting tumorigenesis via disruptions in the hom

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Psychosocial challenges and coping strategies among people with minority gender and sexual identities in Zambia: health promotion and human rights implications

ABSTRACTBackground Sexual and gender minorities face high levels of stigma, discrimination, and violence.In many countries, they are often criminalized and are at risk of mental health challenges.In Zambia, little is known about the psychosocial challenges and coping strategies of sexual and gender minorities.This study sought to explore psychosoci

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Persistent T cell-mediated immune responses against Omicron variants after the third COVID-19 mRNA vaccine dose

IntroductionThe prime-boost COVID-19 mRNA vaccination strategy has proven to be effective against severe COVID-19 disease and death.However, concerns have been raised due to decreasing neutralizing antibody levels after COVID-19 vaccination and due to the emergence of new immuno-evasive SARS-CoV-2 variants that may require additional booster vaccin

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